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Anti-D Plasma Donation Program


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How can I help save lives?

If you have Rh-negative blood, you have the ability to produce anti-D antibodies, which are needed to create an important Rh immune globulin medication.

This medication is given to women who are Rh negative during and after pregnancy to prevent hemolytic disease of the newborn (HDN), a condition where the immune system of a mother who is Rh negative attacks her baby's Rh positive blood often resulting in the death of the baby. If you are female, you may have received this medication during pregnancy and after delivery.

It is estimated that each year, nearly 1 million pregnancies are impacted by the potential of Rh sensitization, which may lead to HDN.1,2  Rh immune globulin medication can only be created from anti-D antibodies found in human plasma. These antibodies cannot be created in a laboratory.

A number of our existing plasma donors are women and men who suffered the heartbreak of losing a child before this medication became available. They donate now to save future generations of children by giving the gift of life.

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How does the Anti-D Plasma Donation Program work?

If you are Rh negative, you have the ability to produce anti-D antibodies in your plasma. Both men and women with negative blood types (A-, B-, AB-, and O-) are Rh negative.

Most people will need to periodically receive red blood cell immunizations to stimulate the production of anti-D antibodies. If you are a woman and had blood incompatibilities during pregnancy, you may already have anti-D antibodies.

Once you start producing anti-D antibodies, you can start donating plasma.


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What if I am not sure if I am Rh negative?

We can do a simple blood test during your visit to our plasma center to find out if you are Rh negative. If you are not Rh negative, we have a variety of additional specialty plasma donation programs that may be of interest to you. Be sure to ask a member of our team for more information.


Why should I participate in this program?

As an anti-D plasma donor, you help create an Rh immune globulin medication that prevents HDN. Without plasma donors like you, this medication would not be available.

The donors participating in this program are provided special compensation for their time associated with each plasma donation and red blood cell immunizations. For more information on specific compensation, please contact one of the plasma centers listed below.


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References: 1. Hirose TG, Mays DA. The safety of RhIG in the prevention of haemolytic disease of the newborn. J Obstet Gynaecol. 2007 Aug;27(6):545-557. 2. Curtin SC, Abma JC, Kost K. 2010 pregnancy rates among U.S. women. Centers for Disease Control and Prevention website. https://www.cdc.gov/nchs/data/hestat/pregnancy/2010_pregnancy_rates.pdf. December 2015. Accessed April 19, 2018.